Dibucaine
Dibucaine is a local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted. The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
Indications[edit | edit source]
Dibucaine is used for:
- Surface anesthesia
- Spinal anesthesia
- Epidural anesthesia
Mechanism of Action[edit | edit source]
Dibucaine blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
Side Effects[edit | edit source]
The side effects of Dibucaine can include:
- Nervousness
- Dizziness
- Blurred vision
- Tremors
- Seizures
Contraindications[edit | edit source]
Dibucaine is contraindicated in patients with known hypersensitivity to the drug or its components.
Interactions[edit | edit source]
Dibucaine may interact with other drugs such as:
- Antihypertensives
- Beta-blockers
- Calcium channel blockers
See Also[edit | edit source]
References[edit | edit source]
| Dibucaine Resources | |
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Contributors: Prab R. Tumpati, MD
