Dibucaine

Dibucaine is a local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted. The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.

Indications

Dibucaine is used for:

• Surface anesthesia
• Spinal anesthesia
• Epidural anesthesia

Mechanism of Action

Dibucaine blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.

Side Effects

The side effects of Dibucaine can include:

• Nervousness
• Dizziness
• Blurred vision
• Tremors
• Seizures

Contraindications

Dibucaine is contraindicated in patients with known hypersensitivity to the drug or its components.

Interactions

Dibucaine may interact with other drugs such as:

• Antihypertensives
• Beta-blockers
• Calcium channel blockers

See Also

• Local Anesthetics
• Amide Type Anesthetics
• Surface Anesthesia
• Spinal Anesthesia
• Epidural Anesthesia

References

Dibucaine Resources
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