Dibutyrylmorphine

Dibutyrylmorphine is a semi-synthetic opioid derivative of morphine. It is a potent analgesic that is used in the treatment of severe pain. Dibutyrylmorphine is also known as dibutyl morphine and butylmorphine.

Chemistry

Dibutyrylmorphine is a morphine derivative where the 3 and 6 hydroxyl groups have been replaced by butyrate esters. This modification results in a compound that is approximately 1.5 times more potent than morphine. The chemical formula of dibutyrylmorphine is C29H38N2O5.

Pharmacology

Dibutyrylmorphine acts on the mu opioid receptor in the central nervous system to produce its analgesic effects. It is metabolized in the liver by cytochrome P450 enzymes and is excreted in the urine.

Clinical Use

Dibutyrylmorphine is used in the treatment of severe pain, such as that associated with cancer or major surgery. It is typically administered via injection. The drug has a rapid onset of action and a relatively short duration of effect, making it suitable for acute pain management.

Side Effects

Common side effects of dibutyrylmorphine include nausea, vomiting, constipation, and drowsiness. More serious side effects can include respiratory depression, hypotension, and dependence.

History

Dibutyrylmorphine was first synthesized in the early 20th century as part of efforts to develop more potent and less addictive alternatives to morphine. However, it was found to have a similar potential for abuse and dependence, and its use has been largely restricted to medical settings.

See Also

• Morphine
• Opioid
• Analgesic
• Cytochrome P450