Diclazepam

Diclazepam

Diclazepam (also known as Chlorodiazepam and 2'-chloro-diazepam) is a benzodiazepine derivative first synthesized in 1960 by Leo Sternbach and his team at Hoffmann-La Roche. It is a psychoactive drug with anxiolytic, sedative, muscle relaxant, and amnesic properties.

Chemistry

Diclazepam is a 2'-chloro derivative of diazepam, and is also a member of the benzodiazepine class. It is structurally related to diazepam in that the benzene ring has been replaced by a thiophene ring.

Pharmacology

Diclazepam has a similar range of effects to other benzodiazepines, including anxiolytic, hypnotic, sedative, amnesic, and muscle relaxant effects. However, it is notably stronger, with a 10 times higher potency than diazepam. It works by binding to the GABA receptor, increasing the efficiency of the neurotransmitter.

Medical Use

While Diclazepam is not currently approved for medical use in many countries, it is used in some countries as a more potent substitute for diazepam in the treatment of anxiety, insomnia, and seizures. It is also used in the treatment of alcohol withdrawal.

Recreational Use

Diclazepam is also used recreationally for its sedative and anxiety-reducing effects. However, it is a controlled substance in many countries due to its potential for abuse and addiction.

Legal Status

The legal status of Diclazepam varies by country. In the United States, it is classified as a Schedule IV controlled substance. In the United Kingdom, it is a Class C drug.

See Also

• Benzodiazepine
• Diazepam
• GABA
• Leo Sternbach
• Hoffmann-La Roche