Diclofenac/misoprostol

Diclofenac/misoprostol is a pharmaceutical drug combination that contains diclofenac, a non-steroidal anti-inflammatory drug (NSAID), and misoprostol, a synthetic prostaglandin E1 (PGE1). This combination is used for the treatment of arthritis in patients at high risk of developing gastric ulcers.

Composition

The drug combination contains diclofenac, which is a phenylacetic acid derivative, and misoprostol, which is a synthetic prostaglandin E1 analogue. Diclofenac is a potent inhibitor of prostaglandin synthesis in vitro, and misoprostol is a synthetic prostaglandin E1 analogue that has gastric antisecretory and, in animals, mucosal protective properties.

Mechanism of Action

Diclofenac works by reducing substances in the body that cause pain and inflammation. Misoprostol protects the stomach from diclofenac's harmful effects by reducing the amount of acid that comes into contact with the stomach lining. This helps to prevent ulcers in the stomach.

Uses

Diclofenac/misoprostol is used to treat osteoarthritis and rheumatoid arthritis in people at high risk of developing stomach or intestinal ulcers. It may also be used for purposes not listed in this medication guide.

Side Effects

Common side effects of diclofenac/misoprostol include nausea, stomach pain, diarrhea, or constipation. Serious side effects may include heart attack, stroke, high blood pressure, bleeding, or perforation (forming of a hole) in the stomach or intestines.

Precautions

Before taking diclofenac/misoprostol, tell your doctor if you are allergic to it; or to aspirin or other NSAIDs; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

See Also

• Nonsteroidal anti-inflammatory drug
• Prostaglandin E1
• Arthritis
• Gastric ulcers