Diethylcarbamazine

Diethylcarbamazine (DEC) is a medication primarily known for its role in the treatment of parasitic worm infections. It is a synthetic organic compound which is highly effective against a variety of parasites. This includes those that cause filariasis, a group of tropical diseases caused by various thread-like parasitic round worms.

Chemistry

Diethylcarbamazine is a derivative of piperazine. Its chemical formula is C10H21N3O, and it is a white, crystalline powder that is soluble in water and alcohol. It is usually administered orally, but can also be given by injection.

Mechanism of Action

The exact mechanism of action of diethylcarbamazine is not fully understood. However, it is believed to work by immobilizing the microfilariae and altering their structure so they can be easily destroyed by the body's immune system. It also has a direct killing effect on the adult worms.

Uses

Diethylcarbamazine is primarily used in the treatment of filariasis, including lymphatic filariasis, onchocerciasis (river blindness), and loiasis. It is also used to treat a condition known as tropical pulmonary eosinophilia, and certain eye infections caused by worms.

Side Effects

Common side effects of diethylcarbamazine include nausea, vomiting, diarrhea, dizziness, headache, and muscle or joint pain. In rare cases, it can cause serious allergic reactions.

Precautions

Before taking diethylcarbamazine, it is important to inform your doctor if you are allergic to it, or if you have any other allergies. It is also important to inform your doctor about your current list of medications, over the counter products, pre-existing diseases, and current health conditions.

See Also

• Antiparasitic
• Filariasis
• Onchocerciasis
• Loiasis

References

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