Digibind
Digibind is a brand name for the drug digoxin immune fab, which is used as an antidote for digoxin toxicity. Digibind is composed of antigen-binding fragments (Fab) derived from specific antibodies that bind to digoxin, a cardiac glycoside used in the treatment of various heart conditions.
Mechanism of Action[edit | edit source]
Digibind works by binding to digoxin molecules in the bloodstream, forming a complex that is then excreted by the kidneys. This binding reduces the free digoxin levels in the blood, thereby mitigating its toxic effects on the heart and other tissues. The Fab fragments in Digibind have a high affinity for digoxin, making it an effective treatment for digoxin overdose.
Indications[edit | edit source]
Digibind is primarily indicated for the treatment of life-threatening digoxin toxicity or overdose. Symptoms of digoxin toxicity can include severe arrhythmias, hyperkalemia, and other cardiovascular complications. It is also used in cases where digoxin levels are significantly elevated and pose a risk to the patient.
Administration and Dosage[edit | edit source]
Digibind is administered intravenously. The dosage of Digibind is calculated based on the amount of digoxin ingested or the serum digoxin concentration. The exact dosage and administration protocol should be determined by a healthcare professional based on the specific circumstances of the overdose.
Side Effects[edit | edit source]
Common side effects of Digibind may include allergic reactions, such as rash or anaphylaxis, and hypokalemia due to the rapid decrease in serum digoxin levels. Patients receiving Digibind should be closely monitored for these and other potential adverse effects.
Contraindications[edit | edit source]
Digibind is contraindicated in patients with known hypersensitivity to sheep-derived proteins, as the Fab fragments are derived from sheep antibodies. Caution is also advised in patients with renal impairment, as the drug is excreted by the kidneys.
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