Dihydroergotamine mesylate

Dihydroergotamine Mesylate (DHE) is a medication used to treat migraine and cluster headaches. It is a derivative of ergotamine, a naturally occurring substance found in the ergot fungus. DHE is administered via injection, nasal spray, or intravenous therapy.

Pharmacology

DHE works by constricting blood vessels in the brain that are dilated during a migraine or cluster headache. It also affects serotonin levels in the brain, which can help to alleviate the pain and other symptoms associated with these conditions.

Uses

DHE is primarily used to treat acute migraine and cluster headaches. It is often used when other treatments have failed. It is not typically used as a first-line treatment due to its potential side effects and the need for administration via injection or intravenous therapy.

Side Effects

Common side effects of DHE include nausea, vomiting, and weakness. More serious side effects can include chest pain, shortness of breath, and heart problems.

Contraindications

DHE should not be used by individuals with certain heart diseases, pregnant women, or those with a history of stroke or blood clots. It should also not be used in conjunction with certain other medications, including triptans and SSRIs.

History

DHE was first synthesized in the 1940s as a derivative of ergotamine. It has been used in the treatment of migraines and cluster headaches since the 1950s.

See Also

• Ergotamine
• Migraine
• Cluster headache
• Serotonin

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