Dimefline

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Dimefline


Dimefline is a stimulant drug that was developed in the mid-20th century. It is chemically related to other stimulant drugs such as amphetamine and ephedrine, but has a unique pharmacological profile.

History[edit | edit source]

Dimefline was first synthesized in the 1950s by the pharmaceutical company Ciba-Geigy. It was initially developed as a potential treatment for hypotension, but was later found to have significant stimulant effects.

Pharmacology[edit | edit source]

Dimefline acts as a norepinephrine-dopamine reuptake inhibitor (NDRI), meaning it increases the levels of the neurotransmitters norepinephrine and dopamine in the brain by blocking their reuptake into neurons. This results in increased neuronal activity, which can lead to increased alertness, energy, and focus.

Medical uses[edit | edit source]

While Dimefline was initially developed for the treatment of hypotension, its stimulant effects have led to its use in other areas. It has been used off-label for the treatment of narcolepsy and attention deficit hyperactivity disorder (ADHD), although it is not officially approved for these uses.

Side effects[edit | edit source]

Like other stimulant drugs, Dimefline can have a number of side effects. These can include insomnia, anxiety, increased heart rate, and increased blood pressure. In rare cases, it can also cause more serious side effects such as psychosis or cardiac arrhythmia.

Legal status[edit | edit source]

Dimefline is a controlled substance in many countries, including the United States and the United Kingdom. It is classified as a Schedule II drug in the United States, meaning it has a high potential for abuse and is available only by prescription.

See also[edit | edit source]


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Contributors: Prab R. Tumpati, MD