Dipropanoylmorphine

Dipropanoylmorphine is a semi-synthetic opioid derived from morphine. It is a potent analgesic used for the relief of severe pain. Dipropanoylmorphine is not commonly used in the United States due to its high potential for addiction and overdose.

Chemistry

Dipropanoylmorphine is a morphine derivative where the 3 and 6 hydroxyl groups are replaced with propionyl groups. It is chemically similar to other morphine derivatives such as heroin (diacetylmorphine), but it is more lipophilic, which makes it cross the blood-brain barrier more easily and produce more intense effects.

Pharmacology

Dipropanoylmorphine acts primarily on the mu-opioid receptor, but it also has effects on the delta and kappa opioid receptors. It produces analgesia, sedation, euphoria, and respiratory depression. Its effects are similar to other opioids, but it is more potent due to its increased ability to cross the blood-brain barrier.

Medical Use

Dipropanoylmorphine is used for the relief of severe pain. It is not commonly used in the United States due to its high potential for addiction and overdose. However, it is used in some countries under strict medical supervision.

Side Effects

Common side effects of dipropanoylmorphine include nausea, vomiting, constipation, dry mouth, drowsiness, and respiratory depression. It can also cause psychological effects such as euphoria and hallucinations. Long-term use can lead to physical dependence and addiction.

See Also

• Morphine
• Heroin
• Opioid
• Analgesic