Ditan
Overview[edit | edit source]
Lasmiditan is a medication used for the acute treatment of migraines with or without aura in adults. It belongs to a class of drugs known as serotonin receptor agonists, specifically targeting the 5-HT1F receptor. Unlike other migraine medications, lasmiditan does not cause vasoconstriction, making it a suitable option for patients with cardiovascular risk factors.
Mechanism of Action[edit | edit source]
Lasmiditan is a selective agonist of the 5-HT1F receptor, which is a subtype of the serotonin receptor. By activating this receptor, lasmiditan helps to inhibit the release of pro-inflammatory neuropeptides and reduce the transmission of pain signals in the trigeminal system. This action helps alleviate the symptoms of a migraine attack.
Pharmacokinetics[edit | edit source]
Lasmiditan is administered orally and is rapidly absorbed, with peak plasma concentrations occurring approximately 1.8 hours after dosing. It is metabolized primarily by non-CYP enzymes and is excreted mainly in the urine. The half-life of lasmiditan is approximately 5.7 hours, allowing for effective relief of migraine symptoms.
Clinical Use[edit | edit source]
Lasmiditan is indicated for the acute treatment of migraine attacks. It is not intended for the preventive treatment of migraines. Patients are advised to take lasmiditan as soon as possible after the onset of migraine symptoms. The recommended dose is 50 mg, 100 mg, or 200 mg, depending on the severity of the migraine and the patient's response to the medication.
Side Effects[edit | edit source]
Common side effects of lasmiditan include dizziness, fatigue, paresthesia, and somnolence. Due to its central nervous system effects, patients are advised not to drive or operate heavy machinery for at least 8 hours after taking lasmiditan.
Contraindications[edit | edit source]
Lasmiditan is contraindicated in patients with hypersensitivity to the drug or any of its components. Caution is advised in patients with severe hepatic impairment, as the pharmacokinetics of lasmiditan may be altered.
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Contributors: Prab R. Tumpati, MD
