Docking protein 6

Docking protein 6 (also known as DOK6 or Dok-6) is a protein that in humans is encoded by the DOK6 gene. DOK6 is part of the DOK (docking protein) family, which acts as adaptors or scaffolds to regulate signal transduction pathways.

Function

DOK6 is a major protein involved in neuronal signal transduction. It plays a crucial role in the neurotrophin signaling pathway, which is responsible for the survival and differentiation of neurons during development. DOK6 promotes neurite outgrowth in neuronal cells.

Structure

The DOK6 protein contains a pleckstrin homology domain at its N-terminus and a phosphotyrosine binding domain at its C-terminus. These domains allow DOK6 to interact with other proteins and play a role in signal transduction.

Clinical significance

Alterations in the DOK6 gene have been associated with several neurological disorders, including Alzheimer's disease and Parkinson's disease. Further research is needed to fully understand the role of DOK6 in these conditions.

See also

• Docking protein
• Neurotrophin
• Signal transduction