Dose dumping
Dose Dumping[edit | edit source]
Dose dumping is a phenomenon in pharmacology where a drug is released from its dosage form more rapidly than intended, leading to potentially dangerous consequences. This can occur when the drug is not properly formulated or when certain conditions cause the drug to be released too quickly.
Causes[edit | edit source]
There are several factors that can contribute to dose dumping, including:
- Inadequate formulation of the drug
- Interaction with other medications
- Alcohol consumption
- Changes in pH levels in the gastrointestinal tract
- Physical damage to the dosage form
Risks[edit | edit source]
Dose dumping can lead to a rapid increase in drug concentration in the body, which may result in:
- Overdose
- Toxicity
- Adverse drug reactions
- Drug interactions
Prevention[edit | edit source]
To prevent dose dumping, pharmaceutical companies must ensure that drugs are properly formulated and tested for stability. Patients should also be educated on the importance of taking medications as prescribed and avoiding interactions that may lead to dose dumping.
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Contributors: Prab R. Tumpati, MD
