Driver
Driver is a term used in various contexts in the medical field. It can refer to a gene or a mutation that drives the progression of a disease, particularly cancer. It can also refer to a factor that drives the spread of disease in a population.
Definition[edit | edit source]
A driver in the context of medicine is a gene or mutation that has been identified as a major contributor to the progression of a disease. This term is most commonly used in the field of oncology, where driver mutations are those that give cancer cells a growth advantage over normal cells. These mutations are the "drivers" of the cancer's growth and progression.
Driver Genes and Mutations[edit | edit source]
In cancer biology, a driver gene is a gene that, when altered or mutated, contributes to the development of cancer. These genes can be divided into two main categories: oncogenes and tumor suppressor genes. Oncogenes, when mutated, can promote cell growth and proliferation, while mutations in tumor suppressor genes can remove the normal constraints on cell growth.
Driver Diseases[edit | edit source]
In epidemiology, a driver disease is a disease that significantly influences the health status of a population. These diseases can drive changes in public health policy and healthcare resource allocation.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
