Dynorphin B

Dynorphin B is a neuropeptide that belongs to the dynorphin family. It is an endogenous opioid that is found in the central nervous system and peripheral tissues. Dynorphin B is known for its role in pain modulation, stress response, and emotional behavior.

Structure

Dynorphin B is a 13-amino acid peptide that is derived from the precursor protein prodynorphin. The sequence of dynorphin B is identical to the C-terminal part of dynorphin A, except that it lacks the N-terminal tyrosine residue.

Function

Dynorphin B acts as a ligand for the kappa opioid receptor (KOR). Upon binding to KOR, it inhibits the release of neurotransmitters and modulates the perception of pain, stress, and emotion. It also has a role in neuroendocrine regulation and immune response.

Clinical significance

Alterations in dynorphin B levels have been associated with various neurological and psychiatric disorders, including chronic pain, depression, schizophrenia, and drug addiction. It is also implicated in the pathophysiology of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

Research

Research on dynorphin B has focused on its potential as a target for the development of new treatments for pain, addiction, and other disorders. Several dynorphin B analogs have been synthesized for this purpose, with varying degrees of success.

See also

• Dynorphin
• Kappa opioid receptor
• Prodynorphin