E-4031

E-4031 is a class III antiarrhythmic agent that is often used in scientific research to understand the properties and effects of hERG potassium channels. It is not used in medical practice due to its potential for inducing torsades de pointes, a specific type of abnormal heart rhythm that can lead to sudden cardiac death.

Mechanism of Action

E-4031 works by blocking hERG potassium channels, which are responsible for the repolarization phase of the cardiac action potential. By blocking these channels, E-4031 prolongs the duration of the action potential, thereby prolonging the QT interval on the electrocardiogram (ECG). This can lead to a type of ventricular tachycardia called torsades de pointes, which can degenerate into ventricular fibrillation and cause sudden cardiac death.

Use in Research

Despite its potential for inducing life-threatening arrhythmias, E-4031 is widely used in research due to its ability to selectively block hERG potassium channels. This makes it a valuable tool for studying the role of these channels in cardiac electrophysiology and for testing the potential cardiotoxicity of new drugs.

Side Effects

The main side effect of E-4031 is the induction of torsades de pointes, a potentially fatal arrhythmia. Other side effects can include dizziness, nausea, and vomiting, although these are less common.

See Also

• Antiarrhythmic agent
• hERG
• Torsades de pointes
• Sudden cardiac death