E-box
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The E-box is a specific DNA sequence that is recognized by certain transcription factors. It plays a crucial role in the regulation of gene expression. The E-box sequence is typically defined as CANNTG, where "N" can be any nucleotide.
Function[edit | edit source]
The E-box is a binding site for basic helix-loop-helix (bHLH) transcription factors, which are involved in various biological processes, including cell differentiation, circadian rhythm, and metabolism. These transcription factors bind to the E-box to regulate the transcription of target genes.
Structure[edit | edit source]
The consensus sequence of the E-box is CANNTG, where the most common sequence is CACGTG. This sequence is found in the promoter regions of many genes and is essential for the binding of bHLH transcription factors.
Biological Significance[edit | edit source]
E-boxes are critical in the regulation of myogenesis, the process of muscle cell formation. They are also involved in the regulation of genes that control the cell cycle and apoptosis.
Related Transcription Factors[edit | edit source]
Several important transcription factors bind to the E-box, including:
These factors are involved in various pathways and can influence oncogenesis, muscle development, and circadian rhythms.
Clinical Relevance[edit | edit source]
Mutations or dysregulation of E-box binding transcription factors can lead to various diseases, including cancer and muscular dystrophy. Understanding the role of E-boxes in gene regulation can provide insights into these conditions and potential therapeutic targets.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
- [E-box on Wikipedia](https://en.wikipedia.org/wiki/E-box)
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Contributors: Prab R. Tumpati, MD