E-selectin

E-selectin (also known as CD62 antigen-like family member E or endothelial-leukocyte adhesion molecule 1 or ELAM-1) is a cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation.

Structure

E-selectin is a 115 kDa glycoprotein that is constitutively expressed at low levels on the surfaces of both vascular endothelial cells and immune cells. The protein encoded by this gene is found in the cytoplasm and is upregulated by inflammatory cytokines.

Function

E-selectin mediates the adhesion of tumor cells to endothelial cells, which may promote tumor cell metastasis. It also plays a crucial role in the recruitment of leukocytes to the site of injury or infection.

Clinical significance

E-selectin is involved in the pathogenesis of various inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. It is also implicated in the process of atherosclerosis.

See also

• Selectin
• Cell adhesion molecule
• Endothelial cells
• Cytokines
• Leukocytes
• Tumor cells
• Metastasis
• Rheumatoid arthritis
• Inflammatory bowel disease
• Atherosclerosis

References

E-selectin Resources
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