EFNA4

EFNA4 is a gene that encodes the Ephrin-A4 protein in humans. Ephrin-A4 is a member of the Ephrin family, which plays a crucial role in the regulation of cell adhesion, growth, and migration.

Function

The EFNA4 gene provides instructions for making a protein called ephrin-A4. This protein is part of a family of ephrin proteins that are attached to the outer surface of cells and interact with Eph receptors on the surface of neighboring cells. These interactions trigger signaling pathways that help control the organization and development of cells and tissues. Ephrin-A4 and its receptors are particularly important in the nervous system, where they guide the movement and organization of nerve cells (neurons) and the growth of their long extensions (axons).

Clinical significance

Mutations in the EFNA4 gene have been associated with various diseases. For example, a mutation in this gene has been linked to Craniofrontonasal syndrome, a rare condition that affects the development of the head and face, hands, and feet.

See also

• Ephrin
• Eph receptor
• Craniofrontonasal syndrome

References

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