EFNB3
EFNB3 is a gene that encodes the ephrin-B3 protein in humans. The protein is a member of the Ephrin family, which plays a crucial role in the regulation of cell adhesion, cell migration, and tissue organization.
Function[edit | edit source]
The Ephrin family members are divided into two classes, ephrin-A and ephrin-B, based on their structures and sequence relationships. The EFNB3 gene belongs to the ephrin-B class. The ephrin-B proteins have a conserved extracellular region, a single transmembrane segment, and a cytoplasmic tyrosine kinase domain. The ephrin-B proteins interact with the Eph family of receptors, which are a large family of receptor tyrosine kinases that play key roles in cell signaling, neural development, angiogenesis, and cancer.
Clinical Significance[edit | edit source]
Mutations in the EFNB3 gene have been associated with Craniofrontonasal syndrome, a rare genetic disorder that primarily affects females and is characterized by abnormalities of the head and face (craniofacial region), hands and feet, and the skeleton.
Research[edit | edit source]
Research on EFNB3 has been focused on its role in neural development and its potential involvement in cancer. Studies have shown that EFNB3 plays a critical role in the guidance of axons during neural development. In cancer, EFNB3 has been implicated in tumor growth and metastasis, although the exact mechanisms are still under investigation.
See Also[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD