EPHX1
EPHX1[edit | edit source]
The structure of the EPHX1 gene.
EPHX1 (Epoxide Hydrolase 1) is an enzyme that plays a crucial role in the metabolism of various xenobiotic compounds and endogenous substrates. It is encoded by the EPHX1 gene, located on chromosome 1p36.22 in humans.
Structure[edit | edit source]
The EPHX1 gene spans approximately 20 kilobases and consists of 12 exons. The gene encodes a protein of 455 amino acids, which forms a homodimer in its active state. The protein contains a catalytic domain responsible for the hydrolysis of epoxides, as well as a membrane-binding domain that anchors it to the endoplasmic reticulum.
Function[edit | edit source]
EPHX1 is primarily involved in the detoxification of various xenobiotic compounds, including environmental pollutants, drugs, and carcinogens. It catalyzes the hydrolysis of epoxides, converting them into less toxic and more water-soluble diols. This enzymatic activity is crucial for the elimination of potentially harmful substances from the body.
In addition to its role in xenobiotic metabolism, EPHX1 also participates in the metabolism of endogenous compounds, such as arachidonic acid epoxides. These epoxides are involved in the regulation of blood pressure, inflammation, and vascular homeostasis. By hydrolyzing these epoxides, EPHX1 contributes to the modulation of these physiological processes.
Clinical Significance[edit | edit source]
Genetic variations in the EPHX1 gene have been associated with altered enzyme activity and susceptibility to various diseases. Certain polymorphisms in the gene have been linked to an increased risk of developing cardiovascular diseases, such as hypertension and atherosclerosis. These variations can affect the efficiency of xenobiotic metabolism and the regulation of endogenous signaling pathways.
Furthermore, EPHX1 polymorphisms have been implicated in the metabolism and toxicity of certain drugs, including carbamazepine and valproic acid. Individuals with specific EPHX1 genotypes may exhibit altered drug response and increased susceptibility to adverse effects.
References[edit | edit source]
See Also[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
