EPH receptor B2

EPH receptor B2 (EPHB2) is a protein that in humans is encoded by the EPHB2 gene. EPHB2 is a member of the EPH receptor family, which is the largest known subfamily of receptor tyrosine kinases (RTKs).

Function[edit | edit source]

EPHB2 functions as the receptor for members of the ephrin-B family and plays a crucial role in the development of the nervous system, particularly in neuronal migration and differentiation. It is also involved in angiogenesis and the development of other tissues, including the gastrointestinal tract and the mammary gland.

Structure[edit | edit source]

The EPHB2 protein is a single-pass type I membrane protein, meaning it crosses the cell membrane once. It contains two fibronectin type-III domains, a sterile alpha motif (SAM), and a protein kinase domain. The extracellular region of the protein interacts with ephrin ligands, while the intracellular region has a tyrosine kinase activity.

Clinical significance[edit | edit source]

Mutations in the EPHB2 gene have been associated with prostate cancer and Alzheimer's disease. In prostate cancer, EPHB2 has been found to be overexpressed, while in Alzheimer's disease, it has been found to be underexpressed.

Research[edit | edit source]

Research is ongoing to understand the role of EPHB2 in disease and to develop potential therapies targeting this receptor. For example, drugs that inhibit EPHB2 activity are being investigated for the treatment of prostate cancer.