EPH receptor B2

From WikiMD's Wellness Encyclopedia

EPH receptor B2 (EPHB2) is a protein that in humans is encoded by the EPHB2 gene. EPHB2 is a member of the EPH receptor family, which is the largest known subfamily of receptor tyrosine kinases (RTKs).

Function[edit | edit source]

EPHB2 functions as the receptor for members of the ephrin-B family and plays a crucial role in the development of the nervous system, particularly in neuronal migration and differentiation. It is also involved in angiogenesis and the development of other tissues, including the gastrointestinal tract and the mammary gland.

Structure[edit | edit source]

The EPHB2 protein is a single-pass type I membrane protein, meaning it crosses the cell membrane once. It contains two fibronectin type-III domains, a sterile alpha motif (SAM), and a protein kinase domain. The extracellular region of the protein interacts with ephrin ligands, while the intracellular region has a tyrosine kinase activity.

Clinical significance[edit | edit source]

Mutations in the EPHB2 gene have been associated with prostate cancer and Alzheimer's disease. In prostate cancer, EPHB2 has been found to be overexpressed, while in Alzheimer's disease, it has been found to be underexpressed.

Research[edit | edit source]

Research is ongoing to understand the role of EPHB2 in disease and to develop potential therapies targeting this receptor. For example, drugs that inhibit EPHB2 activity are being investigated for the treatment of prostate cancer.

See also[edit | edit source]

References[edit | edit source]


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD