ERF (gene)

ERF (gene) is a gene that encodes the ETS2 repressor factor, a member of the ETS family of transcription factors. This gene is involved in a variety of biological processes, including cell growth, differentiation, and apoptosis.

Function

The protein encoded by the ERF gene is a transcriptional repressor that binds to the DNA sequence 5'-CCGGAAGT-3'. It is involved in the regulation of the ETS family of transcription factors, which are involved in a variety of cellular processes, including cell growth, differentiation, and apoptosis.

Clinical significance

Mutations in the ERF gene have been associated with several medical conditions. For example, they have been linked to craniosynostosis, a condition characterized by the premature fusion of the skull bones, and Crouzon syndrome, a genetic disorder characterized by the premature fusion of certain skull bones.

See also

• ETS family
• Transcription factor
• Craniosynostosis
• Crouzon syndrome

External links

• GeneCards - ERF