ERF (gene)
ERF (gene) is a gene that encodes the ETS2 repressor factor, a member of the ETS family of transcription factors. This gene is involved in a variety of biological processes, including cell growth, differentiation, and apoptosis.
Function[edit | edit source]
The protein encoded by the ERF gene is a transcriptional repressor that binds to the DNA sequence 5'-CCGGAAGT-3'. It is involved in the regulation of the ETS family of transcription factors, which are involved in a variety of cellular processes, including cell growth, differentiation, and apoptosis.
Clinical significance[edit | edit source]
Mutations in the ERF gene have been associated with several medical conditions. For example, they have been linked to craniosynostosis, a condition characterized by the premature fusion of the skull bones, and Crouzon syndrome, a genetic disorder characterized by the premature fusion of certain skull bones.
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