E 4031

E-4031 is a class III antiarrhythmic agent that is commonly used in scientific research to understand the properties and effects of this class of drugs. E-4031 blocks human Ether-à-go-go-Related Gene (hERG) potassium channels, which prolongs the duration of the action potential of the cardiac muscle, thereby prolonging the QT interval seen on an ECG.

Mechanism of Action[edit | edit source]

E-4031 works by blocking the rapid component of the delayed rectifier potassium channel current, I(Kr), in the heart. This results in a prolongation of the action potential duration and the QT interval on the ECG, which can lead to a type of ventricular tachycardia called Torsades de pointes.

Uses[edit | edit source]

E-4031 is primarily used in research to study the effects of class III antiarrhythmic drugs and to induce long QT syndrome in experimental animals. It is also used to study the hERG potassium channel, which is important in drug development due to its role in cardiac repolarization and the risk of drug-induced arrhythmia.

Side Effects[edit | edit source]

As with other class III antiarrhythmic drugs, E-4031 can cause Torsades de pointes, a potentially fatal ventricular arrhythmia. Other side effects can include bradycardia, hypotension, and syncope.