Ef-hand calcium binding domain 2

EF-hand calcium binding domain 2 (also known as EFCAB2) is a protein that in humans is encoded by the EFCAB2 gene. This protein belongs to the family of EF-hand proteins, which are characterized by a helix-loop-helix structural domain, known as the EF-hand domain. This domain is involved in the binding of calcium ions, which is crucial for the function of these proteins.

Structure

The EF-hand calcium binding domain 2 protein consists of two EF-hand domains. Each domain is composed of a 12-residue loop flanked by two alpha-helices, referred to as the E and F helices. The loop region is responsible for binding the calcium ion, while the helices provide structural stability. The EF-hand domain is a common motif found in a large number of calcium-binding proteins, including calmodulin, troponin C, and S100 proteins.

Function

The exact function of the EF-hand calcium binding domain 2 protein is not fully understood. However, it is known that EF-hand proteins play a crucial role in calcium signaling, which is involved in a wide range of cellular processes, including muscle contraction, neuronal signaling, and immune response. Given its structural similarity to other EF-hand proteins, it is likely that EFCAB2 also plays a role in these processes.

Clinical significance

Alterations in the function or expression of EF-hand proteins can lead to a variety of diseases, including neurodegenerative diseases, cardiovascular diseases, and cancer. Further research is needed to determine the specific role of EFCAB2 in these diseases.

See also

• EF-hand
• Calcium signaling
• Protein structure