Ef-hand calcium binding domain 2
EF-hand calcium binding domain 2 (also known as EFCAB2) is a protein that in humans is encoded by the EFCAB2 gene. This protein belongs to the family of EF-hand proteins, which are characterized by a helix-loop-helix structural domain, known as the EF-hand domain. This domain is involved in the binding of calcium ions, which is crucial for the function of these proteins.
Structure[edit | edit source]
The EF-hand calcium binding domain 2 protein consists of two EF-hand domains. Each domain is composed of a 12-residue loop flanked by two alpha-helices, referred to as the E and F helices. The loop region is responsible for binding the calcium ion, while the helices provide structural stability. The EF-hand domain is a common motif found in a large number of calcium-binding proteins, including calmodulin, troponin C, and S100 proteins.
Function[edit | edit source]
The exact function of the EF-hand calcium binding domain 2 protein is not fully understood. However, it is known that EF-hand proteins play a crucial role in calcium signaling, which is involved in a wide range of cellular processes, including muscle contraction, neuronal signaling, and immune response. Given its structural similarity to other EF-hand proteins, it is likely that EFCAB2 also plays a role in these processes.
Clinical significance[edit | edit source]
Alterations in the function or expression of EF-hand proteins can lead to a variety of diseases, including neurodegenerative diseases, cardiovascular diseases, and cancer. Further research is needed to determine the specific role of EFCAB2 in these diseases.
See also[edit | edit source]
References[edit | edit source]
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD