Eliezer Masliah
American neuroscientist and neuropathologist
Eliezer Masliah is a prominent American neuroscientist and neuropathologist known for his extensive research in the fields of neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease. He has made significant contributions to understanding the molecular and cellular mechanisms underlying these disorders.
Early Life and Education[edit | edit source]
Eliezer Masliah was born in Mexico City, Mexico. He pursued his medical degree at the National Autonomous University of Mexico (UNAM), where he developed an interest in the pathology of neurodegenerative diseases. Following his graduation, Masliah moved to the United States to further his studies and research.
Career[edit | edit source]
Masliah began his career in the United States at the University of California, San Diego (UCSD), where he joined the faculty in the Department of Neurosciences. During his tenure at UCSD, he established a laboratory that became renowned for its work on the pathogenesis of neurodegenerative diseases.
In 2016, Masliah was appointed as the Director of the Division of Neuroscience at the National Institute on Aging (NIA), part of the National Institutes of Health (NIH). In this role, he oversees a broad portfolio of research aimed at understanding the aging brain and developing interventions to treat age-related neurological disorders.
Research Contributions[edit | edit source]
Masliah's research has focused on the role of synaptic damage and the accumulation of abnormal proteins in the brain, such as amyloid-beta and alpha-synuclein, in the development of Alzheimer's and Parkinson's diseases. His work has helped to elucidate the pathways leading to neuronal death and has identified potential therapeutic targets.
Alzheimer's Disease[edit | edit source]
In Alzheimer's disease research, Masliah has been instrumental in studying the formation and impact of amyloid plaques and neurofibrillary tangles. His studies have contributed to the understanding of how these pathological features disrupt synaptic function and lead to cognitive decline.
Parkinson's Disease[edit | edit source]
Masliah's work on Parkinson's disease has focused on the aggregation of alpha-synuclein and its role in the degeneration of dopaminergic neurons. He has explored the mechanisms by which these protein aggregates spread through the brain and contribute to the progression of the disease.
Awards and Honors[edit | edit source]
Throughout his career, Masliah has received numerous awards and honors for his contributions to neuroscience and neuropathology. His work has been widely published in leading scientific journals, and he is a sought-after speaker at international conferences.
Related Pages[edit | edit source]
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