Elobixibat
An article about the medication Elobixibat
Elobixibat | |
---|---|
![]() | |
INN | |
Drug class | |
Routes of administration | |
Pregnancy category | |
Bioavailability | |
Metabolism | |
Elimination half-life | |
Excretion | |
Legal status | |
CAS Number | |
PubChem | |
DrugBank | |
ChemSpider | |
KEGG |
Elobixibat is a medication used in the treatment of chronic idiopathic constipation (CIC). It is classified as a bile acid transporter inhibitor, specifically targeting the ileal bile acid transporter (IBAT). By inhibiting this transporter, elobixibat increases the secretion of bile acids into the colon, which in turn stimulates colonic motility and improves bowel function.
Mechanism of Action[edit | edit source]
Elobixibat works by inhibiting the ileal bile acid transporter (IBAT), also known as the apical sodium-dependent bile acid transporter (ASBT). This inhibition reduces the reabsorption of bile acids in the ileum, leading to an increased concentration of bile acids in the colon. The presence of bile acids in the colon enhances fluid secretion and colonic motility, thereby alleviating symptoms of constipation.
Pharmacokinetics[edit | edit source]
Elobixibat is minimally absorbed into the systemic circulation, which limits its systemic side effects. The drug acts locally in the gastrointestinal tract, primarily affecting the ileum and colon. The pharmacokinetic profile of elobixibat supports its use as a targeted therapy for constipation with minimal systemic exposure.
Clinical Use[edit | edit source]
Elobixibat is indicated for the treatment of chronic idiopathic constipation in adults. It is typically administered orally, and the dosage may be adjusted based on the patient's response and tolerance to the medication. Patients using elobixibat may experience an increase in bowel movement frequency and a reduction in straining during defecation.
Side Effects[edit | edit source]
Common side effects of elobixibat include abdominal pain, diarrhea, and flatulence. These side effects are generally mild to moderate in intensity and tend to decrease with continued use of the medication. Patients are advised to report any severe or persistent side effects to their healthcare provider.
Related pages[edit | edit source]
Transform your life with W8MD's budget GLP1 injections from $125 and up biweekly
W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.
Why choose W8MD?
- Comprehensive care with FDA-approved weight loss medications including:
- loss injections in NYC both generic and brand names:
- weight loss medications including Phentermine, Qsymia, Contrave, Diethylpropion etc.
- Accept most insurances for visits or discounted self pay cost.
- Generic weight loss injections starting from just $125.00 for the starting dose
- In person weight loss NYC and telemedicine medical weight loss options in New York city available
Book Your Appointment
Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia and visit Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD