Elobixibat

From WikiMD's Wellnesspedia

Elobixibat is a medication used in the treatment of chronic constipation. It is classified as a bile acid transporter inhibitor, specifically targeting the ileal bile acid transporter (IBAT). Elobixibat is marketed under the brand name Goofice in Japan.

Mechanism of Action[edit | edit source]

Elobixibat works by inhibiting the ileal bile acid transporter, a protein responsible for the reabsorption of bile acids from the intestines. By blocking this transporter, elobixibat increases the amount of bile acids present in the colon. This increase in bile acids stimulates colonic fluid secretion and motility, thereby relieving constipation.

Pharmacokinetics[edit | edit source]

Following oral administration, elobixibat is minimally absorbed into the systemic circulation. It primarily acts locally in the gut. The drug is metabolized in the liver and excreted in the feces.

Clinical Use[edit | edit source]

Elobixibat is used for the treatment of chronic constipation in adults. It is particularly useful in patients who have not responded to other treatments. The typical dose is 10 mg once daily, taken before the first meal of the day.

Side Effects[edit | edit source]

The most common side effects of elobixibat include abdominal pain, diarrhea, and nausea. These side effects are generally mild and resolve on their own with continued use of the medication.

Contraindications[edit | edit source]

Elobixibat is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with bile duct obstruction, severe liver disease, and certain types of bowel obstruction.

Drug Interactions[edit | edit source]

Elobixibat may interact with other drugs that are metabolized by the liver, including certain types of statins, warfarin, and oral contraceptives. Patients should inform their healthcare provider of all medications they are currently taking before starting elobixibat.

References[edit | edit source]

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Contributors: Prab R. Tumpati, MD