Endo180

A receptor involved in the endocytosis of glycoproteins

Endo180, also known as Mannose Receptor C Type 2 (MRC2), is a protein encoded by the MRC2 gene in humans. It is a member of the C-type lectin family and is involved in the endocytosis of glycoproteins.

Structure

Endo180 is a type I transmembrane protein that consists of several distinct domains, including a cysteine-rich domain, a fibronectin type II domain, and multiple C-type lectin-like domains. The structure of Endo180 allows it to bind to a variety of ligands, including collagen and glycoproteins.

Function

Endo180 plays a crucial role in the endocytosis and degradation of extracellular matrix components, particularly collagen. It is involved in the remodeling of the extracellular matrix and has been implicated in processes such as tissue repair, fibrosis, and cancer progression. Endo180 is also known to interact with other proteins, such as urokinase-type plasminogen activator receptor (uPAR), to mediate cellular processes.

Expression

Endo180 is expressed in various cell types, including fibroblasts, macrophages, and endothelial cells. Its expression is regulated by factors such as transforming growth factor-beta (TGF-β) and hypoxia.

Clinical Significance

Altered expression of Endo180 has been associated with several pathological conditions. Overexpression of Endo180 has been observed in certain types of cancer, including breast cancer and prostate cancer, where it may contribute to tumor progression and metastasis. Additionally, Endo180 has been implicated in fibrotic diseases, such as liver fibrosis and pulmonary fibrosis.

See also

• C-type lectin
• Endocytosis
• Extracellular matrix
• Fibrosis
• Cancer