Epipregnanolone

Epipregnanolone, also known as 3β-hydroxy-5β-pregnan-20-one, is a neurosteroid that is produced in the human body. It is a metabolite of the hormone progesterone, and is particularly active in the brain and nervous system.

Production and Metabolism

Epipregnanolone is produced in the body from progesterone through the actions of two enzymes: 5α-reductase and 3α-hydroxysteroid dehydrogenase. It can also be produced from allopregnanolone through the action of the enzyme 3β-hydroxysteroid dehydrogenase.

Biological Activity

Epipregnanolone is a potent negative allosteric modulator of the GABAA receptor, which means it reduces the activity of this receptor. This is in contrast to most other neurosteroids, which are positive allosteric modulators of the GABAA receptor.

Clinical Significance

Due to its activity at the GABAA receptor, epipregnanolone has been investigated for potential use in a number of medical conditions, including epilepsy, anxiety disorders, and depression. However, more research is needed to fully understand its effects and potential uses in medicine.

See Also

• Neurosteroid
• Progesterone
• GABAA receptor
• 5α-reductase
• 3α-hydroxysteroid dehydrogenase
• 3β-hydroxysteroid dehydrogenase

Epipregnanolone Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski