Epithelial sodium channel blocker

From WikiMD's Wellnesspedia

Epithelial Sodium Channel Blockers (ENaC blockers) are a class of drugs that inhibit the Epithelial Sodium Channel (ENaC), a protein that facilitates sodium reabsorption in the kidneys. These drugs are primarily used in the treatment of hypertension and certain kidney diseases.

Mechanism of Action[edit | edit source]

ENaC blockers work by inhibiting the ENaC, a protein found on the apical membrane of the epithelial cells in the kidneys. This protein is responsible for the reabsorption of sodium ions from the urine, which is a crucial process in maintaining the body's fluid and electrolyte balance. By blocking the ENaC, these drugs reduce sodium reabsorption, leading to an increase in the excretion of sodium and water in the urine. This can help to lower blood pressure and reduce fluid overload in conditions such as congestive heart failure.

Clinical Uses[edit | edit source]

ENaC blockers are primarily used in the treatment of hypertension, particularly in patients who have not responded to other antihypertensive drugs. They can also be used in the management of certain kidney diseases, such as nephrotic syndrome, where they can help to reduce proteinuria and edema.

Examples[edit | edit source]

Examples of ENaC blockers include amiloride and triamterene. These drugs are often used in combination with other antihypertensive drugs, such as thiazide diuretics, to enhance their efficacy and reduce the risk of side effects.

Side Effects[edit | edit source]

The most common side effects of ENaC blockers are related to their diuretic effect and include increased urination, dehydration, and electrolyte imbalances. In rare cases, they can also cause hyperkalemia, a potentially serious condition characterized by high levels of potassium in the blood.

Future Research[edit | edit source]

Research is ongoing into the development of new ENaC blockers and their potential uses in other conditions, such as cystic fibrosis and chronic obstructive pulmonary disease (COPD).

Resources[edit source]

Latest articles - Epithelial sodium channel blocker

PubMed
Clinical trials
UpToDate

AI tools[edit source]

Generative AI tools and links to learn more on Epithelial sodium channel blocker: ChatGPT - Bing Chat - Google Gemini. (caution advised).


Wiki.png

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD


Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.


Contributors: Prab R. Tumpati, MD