Epitope

Epitope

An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. The ability of an antigen to bind to an antibody's paratope, or a T-cell receptor, is vital for the immune response in the body.

Structure

Epitopes can be categorized into two types: conformational epitopes and linear epitopes. Conformational epitopes are formed by the three-dimensional structure of the antigen, while linear epitopes are formed by the primary sequence of the antigen's amino acids.

Recognition by the Immune System

The immune system recognizes epitopes through a process called immunological memory. This process allows the immune system to respond more rapidly and effectively to pathogens that have been encountered previously.

Role in Vaccine Development

Understanding the structure and function of epitopes is crucial in the development of vaccines. By identifying the epitopes that an immune response targets, scientists can design vaccines that mimic these epitopes, thereby stimulating an immune response.

See Also

• Antigen
• Antibody
• Immunological memory
• Vaccine

References

Epitope Resources
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