Eprosartan
Information about Eprosartan[edit source]
Eprosartan is an angiotensin II receptor blocker used in the therapy of hypertension.
Liver safety of Eprosartan[edit source]
Eprosartan is associated with a low rate of transient serum aminotransferase elevations but has yet to be linked to instances of acute liver injury.
Mechanism of action of Eprosartan[edit source]
Eprosartan (ep" roe sar' tan) is an angiotensin II receptor blocker (ARB) used alone or in combination with other agents for therapy of hypertension. Eprosartan inhibits the renin-angiotensin system by blocking the angiotensin II type 1 receptor (AT1), which prevents the vasoconstriction and volume expansion induced by circulating angiotensin II thus accounting for its antihypertensive activity.
FDA approval information for Eprosartan[edit source]
Eprosartan was approved for use in the United States in 1997 for the treatment of hypertension.
Dosage and administration for Eprosartan[edit source]
Eprosartan is available in 400 and 600 mg tablets generically and under the trade name Teveten. The typical dose in adults in 400 to 800 mg daily in one or two divided doses, and it is used long term. Eprosartan is also available in fixed combinations with hydrochlorothiazide (Teveten HCT).
Side effects of Eprosartan[edit source]
Side effects are uncommon, but can include headache, dizziness, fatigue, edema, cough, gastrointestinal upset, and fetal toxicity. Many ARBs including eprosartan have been linked to rare instances of a severe sprue-like enteropathy that presents with chronic diarrhea and weight loss and villous flattening and atrophy on intestinal biopsy. The diarrhea usually arises after 6 months or more of therapy and does not respond to corticosteroids or a gluten-free diet, but does resolve promptly with stopping eprosartan. This adverse side effect is most common wtih olmesartan.
The common ARBS are the following:
Common ACE inhibitors include the following:
- Benazepril
- Captopril
- Enalapril
- Fosinopril
- Lisinopril
- Moexipril
- Perindopril
- Quinapril
- Ramipril
- Trandolapril
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