Equipoise

A state of uncertainty where a person believes it is equally likely that either of two treatment options is better.

A state of uncertainty on the part of an investigator or a community of investigators regarding the relative merits of interventions. From middle French terms meaning equal weight. Equipoise is an ethical problem when a professional believes one study intervention is superior. Randomly assigning groups of persons to the alternative intervention thus conflicts with an obligation to do the best for the patient or community. “Community” or “clinical” equipoise—collective professional uncertainty—may be invoked to make trial participation ethically acceptable.

Expectation of real uncertainty on the part of the investigator regarding the comparative therapeutic merits of each arm in a trial.

Also called therapeutic equipoise.

Equipoise Resources
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