Esmodafinil

Esmodafinil is a psychostimulant used to treat sleep disorders such as narcolepsy, shift work sleep disorder, and obstructive sleep apnea. It is the enantiopure compound of the racemic modafinil, with a longer half-life than the latter.

Pharmacology

Esmodafinil acts as a dopamine reuptake inhibitor, increasing the amount of dopamine in the brain. It also has effects on other neurotransmitters such as norepinephrine and serotonin, but these are less well understood. Esmodafinil has a longer half-life than modafinil, meaning it remains active in the body for a longer period of time.

Medical uses

Esmodafinil is used to treat excessive sleepiness caused by narcolepsy, shift work sleep disorder, or obstructive sleep apnea. It is also used off-label for conditions such as chronic fatigue syndrome, fibromyalgia, and attention deficit hyperactivity disorder (ADHD).

Side effects

Common side effects of esmodafinil include headache, nausea, dizziness, and difficulty sleeping. Serious side effects may include allergic reactions, psychiatric symptoms, and heart problems.

Interactions

Esmodafinil can interact with a number of other medications, including antidepressants, antiepileptics, and contraceptives. It is important to inform your healthcare provider of all medications you are currently taking before starting esmodafinil.

See also

• Modafinil
• Stimulant
• Sleep disorders