Estradiol enanthate

Estradiol enanthate (EEN), also known as estradiol heptanoate, is a synthetic, steroidal estrogen and an estrogen ester. It is an estrogen ether of estradiol, a naturally occurring female sex hormone. EEN is used in hormone therapy for the treatment of menopausal symptoms and low estrogen levels in women. It is also used in contraceptive injections in combination with progestin.

Pharmacology

Estradiol enanthate is a prodrug of estradiol, meaning it is metabolized in the body into estradiol. It is administered via intramuscular injection and has a long duration of action due to its enanthate (heptanoate) ester. The enanthate ester makes the estradiol lipid-soluble, allowing it to be stored in fat tissue and slowly released over time.

Medical Uses

Estradiol enanthate is used primarily in hormone therapy for menopausal symptoms such as hot flashes, vaginal dryness, and osteoporosis. It is also used to treat hypoestrogenism, a condition characterized by low estrogen levels. In addition, EEN is used in contraceptive injections, often in combination with a progestin.

Side Effects

Like all medications, estradiol enanthate can cause side effects. Common side effects include breast tenderness, nausea, headache, and bloating. More serious side effects can include blood clots, stroke, and an increased risk of certain types of cancer.

See Also

• Estradiol
• Estrogen
• Hormone therapy
• Contraceptive injection

References

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