Estriol triacetate

Estriol triacetate

Estriol triacetate is a synthetic form of estriol, a naturally occurring estrogen hormone. It is used in hormone replacement therapy (HRT) for women who have low estrogen levels, such as those who are postmenopausal or who have had their ovaries removed.

Chemical Structure and Properties

Estriol triacetate is a steroid hormone with the chemical formula C22H30O5. It is a derivative of estriol, with three acetyl groups attached to the oxygen atoms in the estriol molecule. This modification increases the hormone's lipophilicity, allowing it to be more easily absorbed into the body.

Pharmacology

Estriol triacetate works by binding to estrogen receptors in the body, mimicking the effects of natural estrogen. This can help to alleviate symptoms of estrogen deficiency, such as hot flashes, vaginal dryness, and bone loss. However, like all forms of HRT, estriol triacetate carries risks, including an increased risk of breast cancer and cardiovascular disease.

Clinical Use

Estriol triacetate is typically administered orally, in the form of a pill. The dosage will depend on the individual patient's needs and the specific condition being treated. It is important for patients to take this medication exactly as prescribed by their healthcare provider, and to have regular check-ups to monitor their response to the treatment.

Side Effects and Contraindications

Common side effects of estriol triacetate include nausea, bloating, breast tenderness, and changes in menstrual periods. More serious side effects can include blood clots, stroke, and heart attack. This medication is contraindicated in women who are pregnant or breastfeeding, and in those with a history of certain health conditions, including liver disease, certain types of cancer, and blood clotting disorders.

See Also

• Estrogen
• Hormone replacement therapy
• Menopause
• Oophorectomy

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