Ethyl oleate
Ethyl oleate is an ester formed by the condensation of oleic acid and ethanol. It is a colorless to light yellow liquid. Ethyl oleate is produced by the body during ethanol intoxication and is used in the pharmaceutical industry as a solvent for pharmaceutical drug formulations. It is also used in fragrances, flavorings, cosmetics, and as a plasticizer.
Ethyl oleate is classified as a fatty acid ester and is one of the fatty acid ethyl esters (FAEEs). FAEEs are a group of esters of fatty acids with ethanol. Ethyl oleate is produced naturally in the body from ethanol and oleic acid (a common fatty acid in human diet) through the action of the enzyme fatty acid ethyl ester synthase.
In the pharmaceutical industry, ethyl oleate is used as a solvent for the preparation of lipophilic drugs and vitamins. Its low toxicity and agreeable odor and taste make it suitable for use in oral medications and as an excipient in some parenteral formulations. It is also used in the manufacture of soft gelatin capsules.
In addition to its pharmaceutical applications, ethyl oleate finds use in the production of perfumes, flavorings, and cosmetics. Its solubility and non-toxic nature make it an ideal carrier for fragrances and flavors. It is also used as a plasticizer in various industrial applications, improving the flexibility and durability of materials.
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Contributors: Prab R. Tumpati, MD