Ethylphenidate

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Ethylphenidate (EPH) is a psychostimulant and a nootropic. It is closely related to methylphenidate in terms of structure and effects.

Chemistry[edit | edit source]

Ethylphenidate is composed of phenethylamine and piperidine classes. It is a chiral compound, and the compound marketed is a racemic mixture of the R and S isomers.

Pharmacology[edit | edit source]

Ethylphenidate acts as both a dopamine reuptake inhibitor and a norepinephrine reuptake inhibitor, meaning it effectively boosts the levels of the norepinephrine and dopamine neurotransmitters in the brain, by binding to, and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft.

Effects[edit | edit source]

The effects of ethylphenidate are very similar to those of methylphenidate. It increases alertness, cognition, endurance, and motivation, and causes euphoria, and changes in desire for sex.

Legal Status[edit | edit source]

Ethylphenidate is not controlled in the United States. It is, however, an analogue of a Schedule II drug, methylphenidate, and could possibly be considered a controlled substance analogue under the Federal Analogue Act if sold for human consumption.

See Also[edit | edit source]

Ethylphenidate Resources
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Contributors: Prab R. Tumpati, MD