FCER1G

FCER1G is a gene that encodes the gamma subunit of the high affinity IgE receptor, a member of the immunoglobulin superfamily. This gene is located on chromosome 1q23, a region that is often amplified in pre-B-cell acute lymphoblastic leukemia and in some multiple myeloma cell lines.

Function

The FCER1G gene encodes a subunit of the immunoglobulin E receptor (IgE receptor). The IgE receptor is a high affinity receptor for IgE, an antibody isotype involved in allergy and asthma, and is expressed on the surface of mast cells and basophils. The FCER1G subunit is necessary for the function of the IgE receptor, as it is required for signal transduction following receptor activation by IgE.

Clinical significance

Mutations in the FCER1G gene have been associated with susceptibility to asthma, a common chronic inflammatory disease of the airways. In addition, the FCER1G gene has been implicated in the pathogenesis of other allergic diseases, such as atopic dermatitis and allergic rhinitis.

Research

Research on the FCER1G gene has focused on its role in the immune response, particularly in the context of allergic diseases. Studies have shown that variations in the FCER1G gene can affect the function of the IgE receptor, potentially influencing the severity of allergic reactions.

See also

• Immunoglobulin E
• Mast cell
• Basophil
• Asthma
• Atopic dermatitis
• Allergic rhinitis