FERM and PDZ domain containing 2

FERM and PDZ domain containing 2 (also known as FRMPD2) is a protein that in humans is encoded by the FRMPD2 gene. This protein is a member of the FERM domain family, and also contains a PDZ domain.

Function

The FRMPD2 protein is a member of the FERM domain family, named for the four proteins in which it was originally identified: 4.1 protein, ezrin, radixin, and moesin. These proteins are involved in the linkage of the cytoskeleton to the plasma membrane, playing a crucial role in maintaining cell shape and integrity.

The PDZ domain in FRMPD2 is a common structural domain in signaling proteins. PDZ domains bind to the C-terminus of other proteins, playing a role in the assembly of protein complexes at the cell membrane.

Clinical significance

While the exact role of FRMPD2 in human health and disease is not fully understood, alterations in FERM and PDZ domain proteins have been implicated in a variety of diseases, including cancer, neurological disorders, and cardiovascular diseases.

See also

• FERM domain
• PDZ domain
• Protein domain

References

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