FGF10

FGF10 or Fibroblast Growth Factor 10 is a protein that in humans is encoded by the FGF10 gene. It is part of the fibroblast growth factor (FGF) family, which is involved in a variety of biological processes, including cell growth, morphogenesis, tissue repair, tumor growth, and invasion.

Function

FGF10 is a paracrine signaling molecule that plays a crucial role in the development of many tissues and organs in the embryo, including the lung, limb, and mammary gland. It functions by binding to its receptor, FGFR2b, and activating downstream signaling pathways that regulate cell proliferation, survival, migration, and differentiation.

Clinical Significance

Mutations in the FGF10 gene are associated with several human diseases. For example, they can cause LADD syndrome, a rare genetic disorder characterized by defects in the development of the lacrimal and salivary glands, hearing loss, and dental abnormalities. Mutations in FGF10 have also been linked to aplasia of lacrimal and salivary glands, a condition that affects the development of these glands.

Research

Research on FGF10 has provided valuable insights into the mechanisms of organogenesis and tissue repair. It has also led to the development of potential therapeutic strategies for diseases such as chronic obstructive pulmonary disease (COPD), lung fibrosis, and cancer.

See Also

• Fibroblast Growth Factor
• FGFR2b
• LADD syndrome
• Aplasia of lacrimal and salivary glands