FGF4

FGF4 or Fibroblast Growth Factor 4 is a protein that in humans is encoded by the FGF4 gene. It is a member of the fibroblast growth factor (FGF) family, which is involved in a variety of biological processes, including cell growth, morphogenesis, tissue repair, tumor growth, and invasion.

Function[edit | edit source]

FGF4 has been shown to play a key role in the proliferation and differentiation of a wide variety of cells and tissues. It is a potent mitogen for the growth of fibroblasts, myoblasts, and endothelial cells. FGF4 also plays a crucial role in embryonic development, including limb and nervous system development.

Gene[edit | edit source]

The FGF4 gene is located on the q26.3 region of chromosome 11 in humans. It is approximately 1.5 kilobases in length and consists of three exons and two introns. The gene encodes a protein of 206 amino acids.

Clinical significance[edit | edit source]

Mutations in the FGF4 gene have been associated with a variety of diseases and disorders. For example, overexpression of FGF4 has been observed in several types of cancer, including breast cancer, lung cancer, and colorectal cancer. In addition, FGF4 has been implicated in the development of rheumatoid arthritis and other inflammatory diseases.