FGF6

FGF6 or Fibroblast Growth Factor 6 is a protein that in humans is encoded by the FGF6 gene. It is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

Function[edit | edit source]

FGF6 is a unique member of the FGF family because it lacks a conventional signal peptide and is secreted by an alternative mechanism. The specific function of FGF6 has not yet been determined; however, it may play a role in wound healing and muscle regeneration since it is expressed in activated fibroblasts and myoblasts.

Gene[edit | edit source]

The FGF6 gene is located on the q arm of chromosome 12 at position 21. It spans 11,519 base pairs and is located on the Crick (minus) strand. The FGF6 gene produces 2 isoforms through alternative splicing.

Clinical significance[edit | edit source]

Mutations in this gene can lead to autosomal dominant Kallmann syndrome 2. Further studies are needed to determine the specific role of this gene in disease.