FGF6

FGF6 or Fibroblast Growth Factor 6 is a protein that in humans is encoded by the FGF6 gene. It is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

Function

FGF6 is a unique member of the FGF family because it lacks a conventional signal peptide and is secreted by an alternative mechanism. The specific function of FGF6 has not yet been determined; however, it may play a role in wound healing and muscle regeneration since it is expressed in activated fibroblasts and myoblasts.

Gene

The FGF6 gene is located on the q arm of chromosome 12 at position 21. It spans 11,519 base pairs and is located on the Crick (minus) strand. The FGF6 gene produces 2 isoforms through alternative splicing.

Clinical significance

Mutations in this gene can lead to autosomal dominant Kallmann syndrome 2. Further studies are needed to determine the specific role of this gene in disease.

See also

• Fibroblast growth factor
• Kallmann syndrome 2
• Chromosome 12

External links

• GeneCards: FGF6