FGFR1OP
FGFR1OP
FGFR1OP is a gene that encodes a protein known as FGFR1 oncogene partner. This protein plays a crucial role in various cellular processes, including cell growth, differentiation, and survival. Mutations in the FGFR1OP gene have been associated with certain types of cancer and developmental disorders.
Function[edit | edit source]
The FGFR1OP protein interacts with fibroblast growth factor receptor 1 (FGFR1) and modulates its activity. This interaction is essential for the regulation of cell proliferation and differentiation. Additionally, FGFR1OP has been implicated in the development of certain tissues and organs during embryogenesis.
Clinical Significance[edit | edit source]
Mutations in the FGFR1OP gene have been linked to the pathogenesis of several diseases, including cancer. Aberrant expression of FGFR1OP can lead to uncontrolled cell growth and tumor formation. Furthermore, dysregulation of FGFR1OP has been associated with developmental disorders and genetic syndromes.
Interactions[edit | edit source]
The FGFR1OP protein interacts with various signaling molecules and transcription factors to regulate cellular processes. Notably, its interaction with FGFR1 is crucial for the activation of downstream signaling pathways that control cell fate decisions.
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
