FHL2

FHL2, also known as Four and a half LIM domains 2, is a protein that in humans is encoded by the FHL2 gene. FHL2 is a member of the four-and-a-half-LIM-only protein family. It is a protein that in humans is encoded by the FHL2 gene.

Function

FHL2 is a member of the four-and-a-half-LIM-only protein family. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Four-and-a-half LIM protein 2 interacts with various proteins and may serve as a link between different signaling pathways. Its expression prohibits cell differentiation and promotes cell proliferation in conjunction with the growth factor TGF-beta.

Clinical significance

This gene has been found to be mutated in several types of cancer, and the encoded protein may act as a tumor suppressor, with mutations leading to reduced protein expression in tumors.

Interactions

FHL2 has been shown to interact with:

• Androgen receptor
• Estrogen receptor alpha
• MyoD
• Testin

External links

• NCBI Gene
• UniProt