FOXP2
FOXP2 is a gene which codes for a protein needed for speech and language.
It codes for "Forkhead box protein P2", which is needed for the proper development of speech and language in humans.[1] Versions of this gene occur in many vertebrates, where it generally plays a role in communication (for instance, the development of bird song).
FOXP2 is the first gene found which affects speech and language.[2] The gene is more active in females than in males.[3] In humans, mutations of FOXP2 cause a severe speech and language disorder.[1][4]
FOXP2 is popularly dubbed the "language gene", but this is only partly correct since there are other genes involved in language development.[5] It directly regulates a number of other genes, including CNTNAP2, CTBP1, and SRPX2.[6][7]
Two amino acid substitutions distinguish the human FOXP2 protein from that found in chimpanzees.[8] Evidence suggests that these changes affect the functions of FOXP2.[9][10]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
