FV-100
FV-100 is an investigational antiviral drug developed by Bristol-Myers Squibb for the treatment of herpes zoster, also known as shingles. It is a prodrug of CF-1743, which is a potent inhibitor of varicella zoster virus (VZV).
Mechanism of Action[edit | edit source]
FV-100 is a prodrug that is metabolized into its active form, CF-1743, in the body. CF-1743 inhibits the replication of VZV by interfering with the virus's DNA polymerase, an enzyme that is essential for the virus to multiply.
Clinical Trials[edit | edit source]
Several clinical trials have been conducted to evaluate the efficacy and safety of FV-100 in patients with herpes zoster. In a Phase II clinical trial, FV-100 was found to be more effective than valacyclovir, a commonly used antiviral drug, in reducing the severity and duration of shingles-associated pain.
Potential Advantages[edit | edit source]
FV-100 has several potential advantages over existing antiviral drugs for the treatment of herpes zoster. It is more potent against VZV, has a longer half-life, and may be associated with fewer side effects.
Potential Disadvantages[edit | edit source]
As an investigational drug, FV-100 is not yet approved for use in patients. Its safety and efficacy are still being evaluated in clinical trials.
See Also[edit | edit source]
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