FVB mouse

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FVB Mouse

The FVB mouse is a commonly used strain of laboratory mouse in biomedical research. Known for its albino coat color and friendly temperament, the FVB mouse has been instrumental in various fields of study, including genetics, cancer research, and developmental biology.

Characteristics

The FVB mouse is characterized by its albino coat color, which is due to a mutation in the tyrosinase gene. This mutation results in the absence of melanin production, giving the mouse its distinctive white fur and pink eyes. In addition to its coat color, the FVB mouse is known for its docile and friendly nature, making it a popular choice for researchers working with laboratory animals.

Research Applications

The FVB mouse has been widely used in research due to its susceptibility to certain types of tumors, making it a valuable model for studying cancer. Researchers have also utilized the FVB mouse in studies of cardiovascular disease, diabetes, and neurodegenerative disorders. Its genetic background and well-characterized genome make it a versatile model for a wide range of research applications.

Genetic Background

The FVB mouse strain was developed by researchers at the National Institutes of Health (NIH) in the 1970s through a series of selective breeding experiments. The strain is known for its high reproductive efficiency and relatively short gestation period, making it a practical choice for breeding and maintaining colonies in research facilities.

Future Directions

As research in genetics and biomedicine continues to advance, the FVB mouse is likely to remain a valuable tool for scientists seeking to understand the genetic basis of disease and develop new treatments. By leveraging the unique characteristics of the FVB mouse, researchers can gain insights into complex biological processes and accelerate the pace of discovery in various fields of study.