Factor XIII

Factor XIII (also known as Fibrin Stabilizing Factor) is a protein that plays a crucial role in the blood clotting process. It is a transglutaminase enzyme, which means it catalyzes the formation of covalent bonds between proteins. This is particularly important in the final stages of the clotting process, where Factor XIII cross-links fibrin, stabilizing the clot.

Structure

Factor XIII is a tetramer composed of two A subunits and two B subunits. The A subunits carry the catalytic site of the enzyme, while the B subunits act as carrier molecules, protecting the A subunits from premature activation.

Function

The primary function of Factor XIII is to stabilize the fibrin clot that forms at the site of a wound. It does this by cross-linking the fibrin strands, making the clot more resistant to degradation. This is a crucial step in the clotting process, as it ensures that the clot remains in place long enough for the wound to heal.

Deficiency

Factor XIII deficiency is a rare genetic disorder characterized by abnormal blood clotting. This can lead to a variety of symptoms, including abnormal bleeding, poor wound healing, and in severe cases, life-threatening bleeding disorders.

Treatment

Treatment for Factor XIII deficiency typically involves regular infusions of Factor XIII concentrate. This can help to prevent bleeding episodes and improve wound healing.

See Also

• Blood clotting
• Fibrin
• Factor XIII deficiency

Factor XIII Resources
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