Estradiol cypionate/testosterone cypionate

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Estradiol cypionate/testosterone cypionate (EC/TC), also known as estradiol cypionate and testosterone cypionate is a combination drug that contains estradiol cypionate (EC), an estrogen, and testosterone cypionate (TC), an androgen/anabolic steroid. It is used in hormone therapy for transgender women and for menopausal hormone therapy.

Etymology[edit | edit source]

The term "estradiol" is derived from "estrus" (period of fertility for female mammals) + "di" (two) + "ol" (a suffix denoting alcohol). "Cypionate" is derived from "cypion", which is a type of acid.

Pharmacology[edit | edit source]

EC/TC is administered via intramuscular injection. Once in the body, EC and TC are released slowly from the depot where they are stored and are then metabolized into estradiol and testosterone, respectively. These two hormones then exert their effects throughout the body.

Uses[edit | edit source]

EC/TC is used in hormone therapy for transgender women, providing them with the estrogen and testosterone that their bodies need. It is also used in menopausal hormone therapy, helping to alleviate symptoms of menopause such as hot flashes and osteoporosis.

Side Effects[edit | edit source]

Possible side effects of EC/TC include nausea, headache, changes in skin color, increased/decreased sexual interest, oily skin, hair loss, and acne. More serious side effects can include mood changes, trouble sleeping, and stomach pain.

See Also[edit | edit source]

Estradiol cypionate/testosterone cypionate Resources
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Contributors: Prab R. Tumpati, MD