Testosterone cypionate

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Testosterone cypionate

Testosterone cypionate is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of low testosterone levels in men. It is also used in hormone therapy for transgender men. Testosterone cypionate is a synthetic derivative of the natural testosterone hormone and is one of several forms of testosterone replacement therapy available. It is administered through injection into muscle usually once every one to four weeks.

Medical Uses[edit | edit source]

Testosterone cypionate is primarily used to treat symptoms of hypogonadism in men, which can result from a failure of the testes to produce sufficient amounts of testosterone due to genetic problems or damage from infections, surgery, or radiation. Symptoms of hypogonadism can include depression, fatigue, loss of libido, erectile dysfunction, and osteoporosis. In addition to its use in men, testosterone cypionate can be prescribed for hormone therapy in transgender men during gender transition to help develop male secondary sexual characteristics such as increased muscle mass, deepening of the voice, and growth of body hair.

Pharmacology[edit | edit source]

Testosterone cypionate is an ester of testosterone which means that it is testosterone with a cypionate ester attached to it. This modification allows the drug to have a longer half-life and a slower release rate after injection, making it a preferred choice for therapeutic use due to its reduced injection frequency. Once administered, testosterone cypionate is stored in the fatty tissues and slowly released over time, maintaining stable blood levels of testosterone.

Side Effects[edit | edit source]

Like all medications, testosterone cypionate can cause side effects. Common side effects include acne, injection site pain, and an increase in red blood cell count which can lead to complications such as thrombosis. More serious side effects can include liver problems, heart disease, and psychiatric effects such as aggression and mood swings. It is important for individuals receiving testosterone cypionate therapy to be monitored regularly by their healthcare provider.

Contraindications[edit | edit source]

Testosterone cypionate should not be used in individuals with known hypersensitivity to testosterone or any of its excipients. It is also contraindicated in men with breast cancer or known or suspected prostate cancer. Pregnant women should avoid handling testosterone cypionate due to the potential for virilization of a female fetus.

Legal Status[edit | edit source]

The legal status of testosterone cypionate varies by country. In the United States, it is classified as a Schedule III controlled substance under the Controlled Substances Act, meaning that it has a recognized medical use but also a potential for abuse and dependence.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD